MCL1 and cancer: ROS promotes cancer cell migration and invasion by impinging on a number of signaling pathways, including actin cytoskeleton, cell adhesion and extracellular matrix degradation.47 Using a scratch wound-healing assay (Figure 4) we show that wound closure is inhibited by Mcl-1 silencing in all three NSCLC cell lines (A549, H1299 and H460).