These findings are significant because there is a growing body of evidence that links increased mitochondrial ROS generation to increased migration, invasiveness and metastasis in a variety of cancers,11,14,18,49 including NSCLC.12 Since Mcl-1 is elevated in about 60% of NSCLCs, at levels greater than that observed in any other cancer types,50 our data identify the Mcl-1/VDAC interaction as a possible therapeutic target that could limit the metastatic potential in lung cancer. The gene discussed is MCL1; the disease is lung cancer.