To help define the phenotypes specifically dependent on a Mcl-1/VDAC interaction, we selected three different NSCLC lines (A549, H1299 and H460) previously demonstrated to be similar, with respect to having high Mcl-1 expression,26,27 but different in their relative levels of Bcl-xL (Figure 4a). The gene discussed is MCL1; the disease is non-small cell lung carcinoma.