AGER and cancer: Several transcription factors, including NF-κB and HIF1α, are required for upregulated RAGE expression in response to stress in cancer and non-cancer cells.20,28,29 To explore whether NF-κB and HIF1α are involved in hypoxia-induced RAGE expression in pancreatic tumor cells, we knocked down NF-κB p65 and HIF1α in Panc02 cells by specific shRNA (Figure 1c) and siRNA (Figure 1d), respectively.