AGER and pancreatic neoplasm: To evaluate whether RAGE is induced by hypoxia, we first treated two individual pancreatic tumor cell lines (mouse Panc02 and human Panc2.03) with cobalt chloride 2 (CoCl2), a widely used chemical inducer of hypoxia.26 As expected,27 CoCl2 prevented HIF1α degradation and increased HIF1α expression.