HIF1A and familial pancreatic carcinoma: Evidence from experimental and clinical studies increasingly points to an important role for hypoxia in the pathogenesis of solid cancers,8 including pancreatic cancer.9, 10, 11, 12, 13, 14 Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that regulates the oxygen supply balance and demand in response to intratumoral hypoxia and aberrantly, with oncogenic mutations.15 HIF1 is a heterodimer composed of an α-subunit (HIF1α) and a β-subunit (HIF1β).