Our study extends our previous work by showing that expression of RAGE is involved in inflammation, metabolism, and autophagy changes in pancreatic cancer growth and progression.18, 19, 20, 21, 22 Preferential binding of RAGE to mutant KRAS also suggest that acquisition of this mutation confers a survival advantage to early precursor and tumor cells in the emergent tumor microenvironment. This evidence concerns the gene AGER and neoplasm.