HMGB1 and pancreatic neoplasm: Similarly, the expression of the HIF1a target genes BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) and BNIP3L/NIX were significantly increased following CoCl2 treatment in pancreatic tumor cells (Figure 1a).26 In contrast, non-target genes (e.g., high mobility group box 1 (HMGB1) and cyclinD1) did not change (Figure 1a).