Consistently, in cultured cardiomyocytes incubated with 30 mmol/l or 50 mmol/l glucose (HG) to mimic hyperglycemia, IL-1β and IL-18 levels were also found significantly increased, indicating an induction of cardiomyocyte pyroptosis (Figures 2c and d). The gene discussed is IL1B; the disease is Hyperglycemia.