Synergistic inhibition of growth of p53 positive and p53 negative human colorectal cancer HCT116 cells in vitro when compared to effects of the individual polyphenols.Curcumin and resveratrol combination also synergistically inhibited tumor growth within severe combined immunodeficient female mice implanted with HCT-116 cells. Proposed mechanism of action: Decrease in proliferation and induction of apoptosis, decreased NF-κB activity, inhibition of activation of epidermal growth factor receptor. Here, NFKB1 is linked to colorectal cancer.