HBV integration leads to the elevated expression of several cellular cancer-related genes, such as TERT, mixed-lineage leukemia 4 (MLL4) (MLL4 is a part of the ASC-2 complex implicated in the p53 tumor suppressor pathway [153]) and CCNE1 (encoding cyclin E1) [154]. The gene discussed is CCNE1; the disease is neoplasm.