Using in vivo and in vitro models, we show the ability of FHIT to inhibit metastasis and EMT through the suppression of metastasis-related and EMT-associated genes including MTDH, HMGA2, VIM, FN1, CDH1 and Snail in non-small-cell lung cancer (NSCLC) cells. The gene discussed is HMGA2; the disease is non-small cell lung carcinoma.