TGFB1 and cancer: In addition, in agreement with previous studies showing that the miR-30 family members inhibit the EMT process and confer epithelial phenotype to cancer cells including pancreatic and hepatocellular carcinomas [34], [35], our data demonstrated that FHIT-activated miR-30c inhibits TGF-β-induced EMT in NSCLC A549 cells through direct targeting of mesenchymal markers, VIM and FN1, and activation of epithelial marker and metastasis suppressor, E-cadherin (Figure 6I).