Interestingly, FHIT loss has been detected frequently during the early onset of disease progression in cancer [16] and the expression of FHIT and miR-30c is gradually decreased during tumor progression (normal tissues < non-metastatic tumors < metastatic tumors), while expression of miR-30c target genes, MTDH and HMGA2, is increased (Figure 6H). Here, HMGA2 is linked to metastatic neoplasm.