KRT5 and infection: We further assessed the expression pattern of additional lytic genes previously shown to be expressed during early de novo infection, such as ORFK8, K5 and vIRF2, and observed decreased expression during infection of shNrf2 cells compared to shRL cells, suggesting an important role for Nrf2 in the expression of the early lytic KSHV genes during de novo infection of HMVEC-d cells (Fig. S9).