Although our analyses identified several AML-related TFs such as PU1, C-Fos, YY1, some of the other AML-related TF regulators such as p300 and C-Myc [48] exhibit either no or rather modest significance (e.g., -statistic 7.58; p-value 0.0059; FDR0.15 for C-Myc) based on our analysis, which may indicate an over-stringent cutoff (FDR0.1) used in the feature selection procedure or the intrinsic difference between the mRNA expression and the cognate TF activities. This evidence concerns the gene EP300 and acute myeloid leukemia.