Among the 18 selected regulators, we propose a novel role of a recently identified miRNA hsa-miR-548p in AML pathogenesis because of its significant target gene enrichments for leukemia-related pathway and its inferred interaction with another prominent feature regulator YY1, whose perturbed expression has been implicated in AML development through interference with the myeloid differentiation program in leukemic progenitor cells [15]. The gene discussed is YY1; the disease is acute myeloid leukemia.