TF and leukemia: To visualize in network context the regulatory relationships between the 18 selected regulators and their predicted leukemia-related target genes, we imported into Cytoscape [54] the TF-gene and miRNA-mRNA pairs involving nonzero connectivity between the 18 regulators and the leukemia genes filtered by leukemia-related pathways from MSigDB [32] and leukemia-related genes from COSMIC [55].