TF and acute myeloid leukemia: Moreover, the AML samples are perhaps the best match to ENCODE Tier 1 K562 erythroleukemia cells (derived from a 53 year-old Chronic Myelogenous Leukemia patient), which by far has the highest number of 97 TFs measured by ChIP-seq experiments [14] and thus justifies our use of the TF occupancy in K562 as surrogates for the AML samples.