AGT and perinatal asphyxia: Li et al. [227] looked at the effects of nicotine in utero and how it may have had an effect on the offspring’s susceptibility to hypoxic-ischemic encephalopathy (HIE) as well as on Angiotensin II (AngII) receptors AT1R and AT2R. AngII, through its receptors, helps regulate the cardiovascular system as well as physiological responses.