MAP3K6 and neoplasm: Furthermore, although expression of MAP3K6 is variable in cervical and ovarian cancer, there is a decrease in MAP3K6 expression, compared to normal tissue, in 75% out of 106 oral, esophageal, gastric and colorectal cancer cell lines tested [10] suggesting that MAP3K6 may have a tumor suppressive role in cancers of the gastrointestinal tract.