The presence of MAP3K6 mutations in the probands of six unrelated families, somatic mutations in sporadic cancers (particularly those of the gastrointestinal tract), evidence from MAP3K6 knockout mice, second-hit mutations or hypermethylation of the wild-type allele in the tumors tested, and its molecular role in inflammation and apoptosis, all suggest that MAP3K6 is an interesting candidate for mutations associated with Familial Gastric Cancer, warranting further study in additional cohorts of CDH1 mutation-negative familial gastric cancer cases. Here, CDH1 is linked to Familial gastric cancer.