Best studied, albeit not in parasite infection, is the regulation of the IFNγ-inducible lmp2 gene, which encodes a component of the 20S proteasome (low molecular mass polypeptide 2) and requires a complex consisting of non-phosphorylated STAT1 and interferon-regulatory factor 1 for promoter binding and basal transcription [46]. Here, IRF1 is linked to parasitic infectious disease.