In HFF cells, both IFNγ treatment and T. cruzi infection resulted in a robust activation of the STAT1-dependent target genes mig1, gbp1, irf1, ido, and stat1, whereas parasite infection alone, but not IFNγ, induced inos and nf-kb gene expression (Fig. 3A). The gene discussed is GBP1; the disease is parasitic infectious disease.