CDH1 and gastric cancer: Although some studies suggest that altered methylation in CDH1 might be involved in carcinogenesis of GC but not development of GC,55 others indicate that accumulation of aberrant methylation might be an important mechanism for GC development.48 There are also studies indicating that the accumulation of DNA methylation might be caused by proliferative changes during tumor progression.49 Moreover, CDH1 methylation seems to be age related,51 making it more complicated to disentangle the exact role of methylation in the initiation and development of GC.