The key role played by TFIIH is illustrated by the fact that several mutations in its XPB, XPD and TTDA subunits lead to the rare autosomal recessive disorders Xeroderma Pigmentosum (XP), sometimes associated with Cockayne syndrome (XP/CS), and Trichothiodystrophy (TTD). Here, GTF2H5 is linked to Cowden syndrome 1.