Notably the extent of suppression of angiogenesis in corneas which was administrated with TNNI2 was similar to that of ipas in corneas [23], suggesting that TNNI2 inhibited angiogenesis in corneas might be mediated by HIF3A Interestingly, three independent reports have shown that TNNI2 acted as an inhibitor of angiogenesis to inhibit tumor growth and metastasis [35]–[37]. Here, HIF3A is linked to neoplasm.