CSF1R and neoplasm: Of note, a number of recent publications evaluating the effect of M-CSFR inhibitors such as GW2580 or PLX3397 on various populations of tumor-infiltrating myeloid cells (TIM) have documented a reduction of not only mature CD11b+Ly6G-Ly6ClowF4/80high TAM, but also of CD11b+Ly6G-Ly6ChighF4/80mid cells, resembling the surface receptor phenotype and morphology of inflammatory (classical) monocytes or monocytic myeloid-derived suppressor cells (MO-MDSC) (105, 114–116).