Despite comparable levels of TAM reduction as PLX3397 therapy, treatment with PLX5622 did not enhance the effect of imatinib on tumor weight, cell number, or histology, suggesting that inhibition of cKit signaling but not M-CSFR signaling is the main factor determining the capacity of tyrosine kinase inhibitors for GAST growth inhibition (111). This evidence concerns the gene KIT and neoplasm.