CSF1R and pancreatic ductal adenocarcinoma: And in mice bearing transplantable pancreatic ductal adenocarcinomas, the M-CSFR inhibitors GW2580 or PLX3397 were even reported to significantly deplete macrophages expressing high levels of MHC-II, but not the more M2-oriented MHC-IIlow or Tie2+ TAM (105).