CSF1R and breast cancer: In that study, mice bearing two independently derived mammary cancer cell lines (4T1.2 and EMT6.5) injected orthotopically into the mammary gland, were treated with the AFS98 neutralizing anti-M-CSFR mAb, with a neutralizing anti-mouse M-CSF mAb, or with two different small molecule inhibitors of M-CSFR (GW2580 or CYC11645).