While these studies focused on investigating the relationship between COX2 expression and the intrinsic regulation of IDO expression by tumor cells, a more recent study has shown a COX2-expressing MCF-7 breast cancer cell line to induce IDO expression by co-cultured fibroblasts, suggesting that paracrine IDO regulatory networks may also be relevant during the process of carcinogenesis (43). This evidence concerns the gene IDO1 and breast carcinoma.