Further work using the Tyr:CreER;BrafCA;Ptenlox/lox inducible transgenic melanoma model, showed that TDLN DCs and tumor-infiltrating DCs associated with developing melanomas expressed elevated levels of known β-catenin target genes including Axin2, Ccnd1, C-myc, and Tcf-7 relative to DCs derived from more distant lymph node tissues. This evidence concerns the gene AXIN2 and melanoma.