PTGS2 and Familial adenomatous polyposis: The initial data linking COX2 biology with carcinogenesis was provided by genetic studies showing that when APCΔ716 mice, which model the colon cancer syndrome, familial adenomatous polyposis, are crossed with mice carrying an inactivating mutation in the Pgst2 gene encoding COX2, offspring develop exhibiting a diminished number of intestinal polyps (36).