WNT5A and neoplasm: While IFN-γ is a rapid inducer of IDO expression in many cell types, studies are now demonstrating that the loss of TβRIII in a TGF-βhi tumor microenvironment promotes durable IDO expression by pDCs while the upregulation of the Wnt5a oncogene results in durable IDO expression by mDC populations (Figures 2C,D).