Work on MLC1 knock-out mice furthermore suggested that MLC1, a membrane protein of unknown function associated to megalencephalic leukoencephalopathy (Leegwater et al., 2001), might stabilize GlialCAM in the plasma membrane and thus act as an additional binding partner within the ClC-2/GlialCAM complex (Hoegg-Beiler et al., 2014). Here, HEPACAM is linked to leukoencephalopathy, megalencephalic.