A t-test of the highest risk group (APOE-ε4, APOJ-C, n = 8) vs. the lowest risk group (non-APOE-ε4, non-APOJ-C, n = 6) reveals that greater AD risk is associated with greater right entorhinal cortex volume by 13.89%, t(12) = 2.27, p = 0.0421, but no difference in left entorhinal cortex volume, p = 0.09 (Figure 3, *p < 0.05). This evidence concerns the gene APOE and Alzheimer disease.