As similar to schizophrenia, two common polymorphisms in the MTHFR gene (C677T and A1298C) might increase the risk of bipolar disorder and predict the development of comorbid metabolic syndrome suggesting the existence of common genetic underpinnings (Peerbooms et al., 2011; Ellingrod et al., 2012). The gene discussed is MTHFR; the disease is bipolar disorder.