CRH and Anxiety: Rhesus monkeys with bilateral lesions of the central nucleus of the amygdala (CeA), the source of the amygdala's fear-related efferent pathways, displayed significantly less fear-related behavior as well as decreased concentrations of CSF corticotropin releasing-factor (CRF) in comparison to controls (Kalin et al., 2004), further highlighting the role of the amygdala in mediating anxiety behaviors and modulation of stress reactivity.