VEGFA and injury: Neuropathic pain related to trauma caused a significant disruption of the BNB. VEGF was expressed by RM. Intraneural injection of serum obtained from animals with nerve injury or treated with LPS generated mechanical allodynia in naive animals. Intraneural injection of fibrinogen also produced a decrease in mechanical thresholds when applied to naive nerves. Such results evidence that blood–borne molecules may contribute to neuropathic pain mechanisms.