In addition, despite the limited information, the decrease in the expression of TREK1, a TWIK-related potassium channel-1 that is related to pain perception (Alloui et al., 2006) and BBB regulation (Bittner et al., 2013, 2014), after colon inflammation (La and Gebhart, 2011) suggests that the involvement of the central nervous barriers in irritable bowel syndrome should be further explored. This evidence concerns the gene KCNK2 and irritable bowel syndrome.