Indirect evidence: patients with migraine with aura exhibited grater plasma concentrations of MMP-2 and MMP-2/TIMP-2 ratios than patients with migraine without aura and controls. CC genotype for C-735T polymorphism and the CC haplotype were linked to higher plasma MMP-2 concentrations in the migraine with aura group. The gene discussed is TIMP2; the disease is migraine with aura.