After further sequencing and genotyping of SLC30A8 in 149 134 individuals, they found that heterozygosity for any of 12 identified protein-truncating variants was associated with a 65% reduced risk of T2D (odds ratio 0.34, P = 1.7 × 10−6) [32]. The gene discussed is SLC30A8; the disease is type 2 diabetes mellitus.