SLAMF1 and lupus nephritis: It has been pointed out that special care should be taken when examining the precise influence of any targeted gene, such as that of RIIB, located in this region on the occurrence of spontaneous autoantibody production and of lupus nephritis, by eliminating any influence of SLAM members in gene-targeted mice generated with 129-derived ES cells and backcrossed into the genetic background of B6 [1,4,5].