Interestingly, while both SLAM haplotypes 1 and 2 in non-autoimmune strains of mice, such as C57BL/6 (B6) and 129/SvJ, respectively, are not harmful when expressed in the original genetic backgrounds of the host strains, SLAM haplotype 2 in 129 mice (SLAM129) renders the hosts susceptible to autoimmunity, ANAs being produced when expressed in the B6 genetic background [4,5]. Here, SLAMF1 is linked to Autoimmunity.