ALB and glomerulonephritis: They observed that RIIB-deficient mice produced only a small amount of anti-ssDNA antibodies spontaneously even at the age of 10 months, exhibited slight IgG-IC deposition in the kidneys, and increases in urinary albumin and the pathological score of glomerulonephritis, without showing mortality at least up to 12 months of age, indicating that RIIB deficiency only amplifies spontaneous autoimmunity determined by other loci.