Therefore, to clarify this issue, the aim of the present study is to assess by immunohistochemistry, the topographic distribution of CD 34 positive fibrocytes and SMA positive myofibroblasts both in axillary lymph node and liver metastases which are frequent in breast carcinoma and strongly associated with an increased risk of distant metastasis and poor overall survival [8]. This evidence concerns the gene SMN1 and breast carcinoma.