In particular according to these data we and others have clearly demonstrated that the loss of CD34 fibrocytes and acquisition of peritumoral myofibroblasts expressing smooth muscle actin (SMA) is a fundamental step both in ductal carcinoma in situ (DCIS) and invasive carcinoma of no special type (NST) [5,6]. The gene discussed is CD34; the disease is ductal breast carcinoma in situ.