PCA3 and Familial prostate cancer: Many lncRNAs have been mapped at cancer risk loci in the human genome, such as PTCSC3 (14q13.3) in thyroid cancer (45,46), PCA3 (9q21–22) in prostate cancer (47,48), ANRIL (9p21) in prostate and breast cancers, leukemia and melanoma (49–52), MALAT1 (11q13) in liver, colorectal, prostate, bladder and lung cancers (53–56).