This hypothesis is further supported by a recent publication establishing that skeletal muscle anti-inflammatory macrophages correlate with insulin sensitivity in obese and type 2 diabetic patients [18] Furthermore, mice overexpressing the anti-inflammatory cytokine IL10 in skeletal muscle and mice full body knock-outs for MCP1 are protected from high-fat diet-induced macrophage infiltration in muscle and insulin resistance [15], [17], which highlights a close relationship between muscle inflammation and insulin sensitivity. This evidence concerns the gene INS and type 2 diabetes mellitus.