MTHFR and esophageal cancer: For esophageal cancer, our data suggested an increased risk among MTHFR rs1801133 T allele carriers (any T vs. C/C, SBOR: 1.25, 95% posterior limits: 0.85, 1.84), which is consistent with findings from a meta-analysis of 19 studies (C/T versus C/C, OR: 1.47, 95% CI: 1.32–1.63; T/T versus C/C, OR: 1.69, 95% CI: 1.49–1.91) [2].