It is known that genetic variants of the TNFAIP3 gene loci were associated with susceptibility to multiple human autoimmune and inflammatory diseases including rheumatoid arthritis (RA), systemic lupus erythematous (SLE), sjogren's syndrome (SS), systemic sclerosis (SSc), psoriasis (PsA) and inflammatory bowel diseases (IBDs) [15]–[17]. The gene discussed is TNFAIP3; the disease is rheumatoid arthritis.