TNFAIP3 and systemic sclerosis: It is known that genetic variants of the TNFAIP3 gene loci were associated with susceptibility to multiple human autoimmune and inflammatory diseases including rheumatoid arthritis (RA), systemic lupus erythematous (SLE), sjogren's syndrome (SS), systemic sclerosis (SSc), psoriasis (PsA) and inflammatory bowel diseases (IBDs) [15]–[17].