Y-27632 has been shown to have contrasting biological effects in different systems, ranging from pro-proliferative effects on hESCs and hiPSCs [48], [49] to anti-proliferative effects on cancer cells [50], cord blood-derived CD34+ hematopoietic progenitor cells [51], hepatic stellate cells [52] and smooth muscle cells [53]. This evidence concerns the gene CD34 and cancer.