EGFR and non-small cell lung carcinoma: In our recent study, we independently established new cellular models of acquired resistance to the EGFR TKI erlotinib in EGFR-mutated lung adenocarcinoma by using the erlotinib-sensitive, EGFR-mutated NSCLC cell line HCC827, and revealed that increased activation of AXL and induction of an EMT-like state was associated with acquired resistance to erlotinib in vitro and in vivo, identifying AXL as a promising therapeutic target to prevent or overcome resistance.