It has been shown that in the H1299 lung cancer cell line expressing different mutant forms of p53, AXL is upregulated upon p53 loss and at least in part gain-of-function activities of mutant p53 were mediated through AXL overexpression as knockdown of AXL by AXL-specific siRNA reduced cell growth and motility [75]. The gene discussed is TP53; the disease is lung cancer.