PLAT and Stroke: When two individual treatments of MINO at 1 hr followed by RIPerC at 2 hrs post-stroke were used in combination, CBF increased significantly compared to the sham-treated group with (p = 0.0017) or without (p < 0.0001) IV-tPA, as well as compared to MINO alone with IV-tPA (p = 0.0058) or without IV-tPA (p = 0.0005) but not when compared to RIPerC alone with IV-tPA (p = 0.5053) or without IV-tPA (p = 0.1958).