PLAT and Stroke: MINO did not improve the CBF significantly with IV-tPA (MINO main effect F(1,24) = 2.76, p = 0.1095) but did without IV-tPA (F(1,27) = 10.01, p = 0.0038), although there was a trend towards increased perfusion at 48 hrs post-stroke possibly due to vascular as well as neuroprotective effects of MINO.