Recent studies have reported that a non-synonymous sequence variation (rs738409 C > G), which encodes an isoleucine to methionine substitution at position 148 (I148M) in PNPLA3, is associated with the susceptibility to fatty liver disease (FLD) and FLD-related liver fibrosis (9-12). The gene discussed is PNPLA3; the disease is Hepatic fibrosis.