Although here was no correlation between the rs738409 polymorphism and HBV-related liver cirrhosis (18), due to a small sample size (76 patients with HBV-related cirrhosis versus 428 control subjects), it lacked sufficient power to determine the effect of PNPLA3 polymorphisms on HBV-related cirrhosis. The gene discussed is PNPLA3; the disease is Cirrhosis.