So far, there have been few studies investigating the association between IL28B rs8099917 gene polymorphisms and treatment response to therapy with PEG-IFN/RBV in Chinese patients with chronic hepatitis C. In our study, frequencies of T allele in healthy people and patients chronically infected with HCV were 95.3% and 92.2%, respectively. Here, IFNL3 is linked to chronic hepatitis C virus infection.