Scisciani et al. identified that p65/NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a direct transcriptional regulator of miR-224 expression and links miR-224 up-regulation with the activation of the LPS, LTα, and TNFα inflammatory pathways, as well as cell migration/invasion in HCC (95). The gene discussed is TNF; the disease is hepatocellular carcinoma.