The results of EIA analyses for Asn88-free RNase1 using the RrhRN0723 mAb did not reliably distinguish patients with PaCa from healthy donors (Fig. 4a center panel, P = 0.594) due to variation in the concentration of total serum RNase1 concentrations. The gene discussed is RNASE1; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.