HGF and cancer: The findings that urinary sMet levels were significantly higher in BCa patients than in individuals with no evidence of cancer, higher in muscle-invasive than in non-invasive cancer, and higher in more malignant pathologic stages, suggest that follow-up prospective clinical studies to investigate its potential utility in disease prognosis, as an aid to disease surveillance, and to identify patients likely to benefit from HGF/Met-targeted therapies, are warranted.