HGF and neoplasm: Consistent with the known role of HGF/Met signaling in tumor invasiveness and the correlation between Met shedding and malignancy found previously, the median urinary sMet/creatinine value of patients with non-muscle invasive BCa (NMIBCa; n = 141) was significantly lower than that of patients with muscle-invasive BCa (MIBCa; n = 42; p < 0.0001; Figure 1C).