SERPINA6 and obesity due to melanocortin 4 receptor deficiency: Lower CBG levels have been linked to obesity and insulin resistance, as it has been shown to affect fat accumulation and muscle development probably due to an increase in circulating GCs [4], [64]–[69], although hypocortisolism has also been associated with CBG deficiency attributed to CBG functioning as a reservoir for endogenous glucocorticoids [70], [71].