Interestingly, in this study and our previous studies on terminal ALS mice and patients, we observed that EOMs maintained relatively well-preserved cytoarchitecture, intact innervation of motor endplates and normal expression of laminins, synaptophysin, and p75 neurotrophin receptor at neuromuscular junctions [19], [20], [55]. Here, SYP is linked to amyotrophic lateral sclerosis.