Moreover, the Wip1 gene is frequently amplified/overexpressed in human cancers, including breast cancers, ovarian clear-cell adenocarcinomas, pancreatic neuroendocrine tumors, neuroblastomas, and pancreatic cancers, all of which rarely carry a p53 mutation [10], [11], [12]. The gene discussed is PPM1D; the disease is familial pancreatic carcinoma.