APP and brain ischemia: From the aqueous extract of Achyranthes bidentata Blume, we isolated Achyranthes bidentata polypeptides (ABPP), which attenuated the glutamate-induced apoptosis in primary hippocampal neurons, supported recovery from experimental cerebral ischemia in vivo[3]–[5], and promoted peripheral nerve regeneration in rodents with sciatic nerve crush through stimulating release of growth factors [6], [7].