CD8A and neoplasm: CD8+ T cells co-cultured with sorafenib-treated E.G7 cells were shown with higher killing effects, activation, and migratory abilities as compared to those co-cultured with untreated E.G7 cells (Figure 3), suggesting that the suppressions of immunosuppressive factors after sorafenib treatment should play a role in tumor microenvironment (Figure 2).