We found that the sum of the weighted adjacency matrix of VAG was significantly larger than that of the randomized signature (P = 0.003 for breast cancer and P<0.001 for colon, liver, lung, pancreatic, and thyroid cancers) (Figure S1), which confirmed the inherent relationship in gene expression among VDAC1 and its interacting genes. The gene discussed is VDAC1; the disease is breast carcinoma.