Paired t-tests indicated that VDAC1 was uniformly up-regulated in tumor tissues across all six cancer types, with a fold change of 1.25 in breast, 1.32 in colon, 1.64 in liver, 1.67 in lung, 1.91 in pancreatic, and 1.14 in thyroid cancers (Figure 1A). Here, VDAC1 is linked to neoplasm.