During thecourse of our study we identified three patients with CT deficiency due to thyroiditis, and threepatients with high CT serum levelsdue to MTC (Supplementary Table 4).Dual-energy X-ray absorptiometry (DEXA) revealed high bone mineral density in patientswith CT deficiency, whereas theopposite was observed in patients with CT excess (Supplementary Fig.6a,b). This evidence concerns the gene CALCA and thyroiditis.