CALCA and thyroid gland disorder: During thecourse of our study we identified three patients with CT deficiency due to thyroiditis, and threepatients with high CT serum levelsdue to MTC (Supplementary Table 4).Dual-energy X-ray absorptiometry (DEXA) revealed high bone mineral density in patientswith CT deficiency, whereas theopposite was observed in patients with CT excess (Supplementary Fig.6a,b).