In a hypothesis-free approach, we further identified collapsin response meditator protein 1 (CRMP1, also known as DPYSL1) as the epitope for an antibody which could discriminate between a pool of aggregated proteins (aggregomes) derived from brain samples of patients with schizophrenia compared to an equivalent pool from control individuals [7]. The gene discussed is CRMP1; the disease is schizophrenia.