To test this, advantage was taken of the fact that NMB and SH-SY5Y neuroblastoma cells both express endogenous TRIOBP-1 protein, to a high level in the case of NMB, and that they can each be induced to differentiate into neuron-like morphologies by treatment with dopamine or retinoic acid/PMA respectively [26], [27]. The gene discussed is NMB; the disease is neuroblastoma.