As an example, the nomogram predicts that a 50-year-old patient (40 points) with stage T1 (0 points), N0 (0 point), ER positive (0 points), grade I (0 points) tumor has a lower than 10% risk (total points, 40) of death from breast cancer within 10 years of surgery. The gene discussed is ESR1; the disease is neoplasm.