The results revealed that the induced rate of apoptosis was ~8% by siRNA-FLIP, 15% by TRAIL and 56% by siRNA-FLIP combined with TRAIL (Fig. 4D and E), suggesting that the downregulation of c-FLIP in the HepG2 cells mimicked the effect of rocaglamide on TRAIL-mediated apoptosis in the TRAIL-resistant HCC cells. Here, CFLAR is linked to hepatocellular carcinoma.