NLRP3 and Hypertension: In Ps, CD14+ cells, AR met the significance threshold while in CD14− cells, RORC, a transcription factor in Th17 cells [43], NR3C1, a glucocorticoid gene with polymorphisms linked to obesity, hypertension, elevated lipid levels and increased cardiovascular risk [44], and PYCARD-an adaptor protein for NLRP3 the inflammasome forming protein [45] had the lowest p values.