Furthermore, no difference in the proliferative response was observed among the four different categories of subjects, including C/C healthy controls, individuals heterozygous for the C/T PTPN22 variant, C/C T1D patients and T1D patients heterozygous for the C/T PTPN22 variant (KS-test p>0.10; one way ANOVA p = 0.6878) (Figure 3A). Here, PTPN22 is linked to type 1 diabetes mellitus.