PTPN22 and type 1 diabetes mellitus: Within the four categories of individuals, the ratio of mature B cell percentages in unstimulated compared with CpG-stimulated PBMC increased without statistical significance in patients that possessed the C/T PTPN22 variant than in C/C T1D patients or healthy controls (KS-test p<0.05; one way ANOVA with Kruskal-Wallis test p = 0.939) (Figure 3B, Figure S10).