Recently, we and others have shown that in diabetic kidney disease in which TGFβ plays a significant role to produce extracellular matrix, administration of rapamycin, which inhibits both mTORC1 and mTORC2 in mice, resulted in marked reduction in matrix proteins including collagen I (α2) [33], [34], [55], [56]. Here, TGFB1 is linked to diabetic kidney disease.