R. serra is famous for its antibacterial, antiviral, anti-inflammatory and antitumor activities, and effusanin E, a compound from natural herb, inhibited NPC cells via disrupting NF-κB signaling and induced apotosis in NPC cells, meanwhile, effusanin E significantly suppressed tumor growth in a xenograft mouse model of NPC cells without obvious toxicity, moreover, the expression of p50 and COX-2 were downregulated in the tumors of nude mice, which are consistent with cell study, so these findings evidenced the antitumor activities of R. serra. This evidence concerns the gene NFKB1 and neoplasm.